Combined from ノ [ノ] + Two [二] + Person [人] + Big / Great [大] to compose 失: represents "disadvantage".
to fail
disqualification, elimination, incapacity (legal)
lack of harmony
loss
losing something
error, blunder, accident
disappointed love, broken heart, unrequited love, be lovelorn
to lose, to part with
unemployment
disappointment, despair
failure, mistake